whve / h.pylori

Tutorials

抗生素	主要耐药机制	主要耐药基因	关键突变位点	备注	来源
克拉霉素	antibiotic target alteration	23S rRNA	A2146G	single resistance variant	PMID: 11120937
克拉霉素	antibiotic target alteration	23S rRNA	A2146C	single resistance variant	PMID: 11120937
克拉霉素	antibiotic target alteration	23S rRNA	A2146U	single resistance variant	PMID: 11120937
克拉霉素	antibiotic target alteration	23S rRNA	A2147C	single resistance variant	PMID: 11120937
克拉霉素	antibiotic target alteration	23S rRNA	A2147G	single resistance variant	PMID: 11120937
四环素	antibiotic target alteration	16S rRNA	A965G	single resistance variant	PMID: 12435699
四环素	antibiotic target alteration	16S rRNA	A965U,G966U,A967C	multiple resistance variants	PMID: 11914344
四环素	antibiotic target alteration	16S rRNA	A965G,A967C	multiple resistance variants	PMID: 12435699
四环素	antibiotic target alteration	16S rRNA	A965G,G966U	multiple resistance variants	PMID: 12435699
四环素	antibiotic target alteration	16S rRNA	A967C	single resistance variant	PMID: 12435699

References:

Alcock BP, Raphenya AR, Lau TTY, et al. CARD 2020: antibiotic resistome surveillance with the comprehensive antibiotic resistance database. Nucleic Acids Res. 2020;48(D1):D517-D525. doi:10.1093/nar/gkz935

Vester B, Douthwaite S. Macrolide resistance conferred by base substitutions in 23S rRNA. Antimicrob Agents Chemother. 2001;45(1):1-12. doi:10.1128/aac.45.1.1-12.2001

Dailidiene D, Bertoli MT, Miciuleviciene J, et al. Emergence of tetracycline resistance in Helicobacter pylori: multiple mutational changes in 16S ribosomal DNA and other genetic loci. Antimicrob Agents Chemother. 2002;46(12):3940-3946. doi:10.1128/aac.46.12.3940-3946.2002

Trieber CA, Taylor DE. Mutations in the 16S rRNA genes of Helicobacter pylori mediate resistance to tetracycline. J Bacteriol. 2002;184(8):2131-2140. doi:10.1128/jb.184.8.2131-2140.2002