This happens when an OCSP responder isn't working and Certgrinderd goes to the next server, more info needed:
2020-10-14 00:00:04 +0000 certgrinder ERROR certgrinderd: OCSP request failed for URL http://ocsp.int-x3.letsencrypt.org with HTTP status code 500 - trying next OCSP server
2020-10-14 00:00:04 +0000 certgrinder WARNING Traceback (most recent call last):
2020-10-14 00:00:04 +0000 certgrinder WARNING File "/home/certgrinderd/virtualenv/bin/certgrinderd", line 8, in <module>
2020-10-14 00:00:04 +0000 certgrinder WARNING sys.exit(main())
2020-10-14 00:00:04 +0000 certgrinder WARNING File "/usr/home/certgrinderd/virtualenv/lib/python3.7/site-packages/certgrinderd/certgrinderd.py", line 1236, in main
2020-10-14 00:00:04 +0000 certgrinder WARNING method()
2020-10-14 00:00:04 +0000 certgrinder WARNING File "/usr/home/certgrinderd/virtualenv/lib/python3.7/site-packages/certgrinderd/certgrinderd.py", line 543, in get_ocsp_command
2020-10-14 00:00:04 +0000 certgrinder WARNING ocsp_response = self.get_ocsp_response(certpath=self.conf["certificate-file"])
2020-10-14 00:00:04 +0000 certgrinder WARNING File "/usr/home/certgrinderd/virtualenv/lib/python3.7/site-packages/certgrinderd/certgrinderd.py", line 608, in get_ocsp_response
2020-10-14 00:00:04 +0000 certgrinder WARNING ), "Unsupported access method, please file a certgrinder bug"
2020-10-14 00:00:04 +0000 certgrinder WARNING AssertionError: Unsupported access method, please file a certgrinder bug
2020-10-14 00:00:04 +0000 certgrinder ERROR Did not get an OCSP response in stdout from certgrinderd
2020-10-14 00:00:04 +0000 certgrinder ERROR Failed getting a new OCSP response for domainset: ['deic-ore.anycast.censurfridns.dk', 'deic-ore.anycast.censurfridns.nu', 'deic-ore.anycast.uncensoreddns.org', 'deic-ore.anycast.uncensoreddns.dk', 'anycast.censurfridns.dk', 'anycast.censurfridns.nu', 'anycast.uncensoreddns.org', 'anycast.uncensoreddns.dk']
reloadAllCertificates()
exporter_exporter: stopped
exporter_exporter: started