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dallphinatom's Issues

1. Simulation Time 설정법에 대한 질문/ 2. Full PBPK에서 CL 오류

0.9.0 ver 설치해서 실행해 보았습니다. 깔끔하게 잘 만들어진것 같습니다.

Basic info 부터 Final Parameters 탭까지는 적당히 값 입력해서 넘어왔고요.
Concentration Prediction tab에서 'Run Simulation' 버튼을 눌렀는데 아무런 결과가 나오지 않습니다.
Simulation Time 부분이 0.0으로 되어 있고 활성화가 되어 있지 않는데 이 부분 때문인것 같습니다.

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참고로 Dosing Interval을 바꾸면 같은 값이 Simulation Time에 업데이트 되고 시뮬레이션이 잘 수행됨을 확인했습니다.
Simulation Time = Number of Doses * Dosing Interval 로 설정되어 있는것 같습니다.
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같은 원리가 Full PBPK 파트에도 적용되는것 같습니다. 추가로 Full PBPK 시뮬레이션 하면 plasma와 tissue concentration 모두 계속 올라가다 떨어지지 않고 유지되는데 제가 입력한 input 값 때문인지 잘 모르겠습니다.
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macOS 용 설치 파일 만들기

자바어플리케이션을 실행할 PC에 자바구동환경( 자바런타임 JRE )이 미리 설치 되어 있어야 한다는 약점이 있습니다.
이 때문에 자바 Swing/AWT등으로 작성된 GUI어플리케이션의 경우 어플리케이션 작성 후 Executable JAR파일을
윈도우용 실행 파일(exe) 혹은 맥용 설치파일(pkg)로 감싸는(Wrapping)하는 단계를 거치게 됩니다.

윈도우 용으로는 launch4j 가 있습니다만

맥용을 만들기 위해서는 다음을 참고합니다.

Error: simulation of IV infusion

There is an error regarding simulation of IV infusion.
I believe that we should review the mrgsolve simulation code again.
After the infusion is finished, the concentration is increasing and this doesn't seem to work properly.

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Calculation error: CL predicted by dallphinAtom using MLP method

  • Error in CL predicted by dallphinAtom using MLP method
  • need to confirm the formula in DallphinAtom to predicte CL with MLP method
    • Result of CL predicted with MLP method (DallphinAtoM v0.9.8.5): 0.0224L/hr/kg (Human BW was setted as 60 kg)
    • Manual calculation: 0.0445L/hr/kg

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