open-systems-pharmacology / probenecid-model

Whole-body PBPK model of probenecid (OAT perpetrator drug)

Probenecid-Model

Mechanistic PBPK model of probenecid (clinical OAT inhibitor)

Repository files

Within this repository, we share a whole-body PBPK model of probenecid. The model was developed using data of 27 clinical studies (dosing range 250–2000 mg), and qualified for DDI prediction with the OAT victim drug furosemide and the OATP1B1 substrate rifampicin.

The PK-Sim project file contains simulations and the observed data of all clinical studies used for model development and evaluation. For further details, quantitative model evaluation, sensitivity analysis and extensive documentation please refer to [1].

Version information

PK-Sim Version 9.0.

Code of conduct

Everyone interacting in the Open Systems Pharmacology community (codebases, issue trackers, chat rooms, mailing lists etc...) is expected to follow the Open Systems Pharmacology code of conduct.

Contribution

We encourage contribution to the Open Systems Pharmacology community. Before getting started please read the contribution guidelines. If you are contributing code, please be familiar with the coding standard.

License

The model is distributed under the GPLv2 License.

Reference

[1] Britz H, Hanke N, Taub ME, Wang T, Prasad B, Fernandez É, Stopfer P, Nock V, Lehr T. Physiologically Based Pharmacokinetic Models of Probenecid and Furosemide to Predict Transporter Mediated Drug-Drug Interactions. Pharm Res. 2020 Nov 25;37(12):250

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