ethinylestradiol-model's Introduction

Ethinylestradiol-Model

Whole-body PBPK model of ethinylestradiol as CYP1A2 DDI perpetrator drug

This repository contains:

a PK-Sim snapshot (*.json) file of the current PBPK model
static content (e.g. text blocks, *.md files) as inputs for an evaluation plan
an evaluation plan (evaluation-plan.json) to create an evaluation report using the snapshot and static text blocks to display the performance of the model

The latest release of the snapshot of the model, the evaluation plan and the static content can be found here.

The latest release of the PK-Sim project model file and the respective evaluation report can be found here.

The presented PBPK model of ethinylestradiol (EE) has been developed to be used in a PBPK DrugDrug-Interactions (DDI) network with ethinylestradiol as perpetrator of CYP1A2. The development of this model is described in the publication by Kanacher et al. [1]

Contacts

For your questions and comments about the models please create a new issue. A full publication about models presented is available at: https://www.mdpi.com/1999-4923/12/12/1191 .

Code of conduct

Everyone interacting in the Open Systems Pharmacology community (codebases, issue trackers, chat rooms, mailing lists etc...) is expected to follow the Open Systems Pharmacology code of conduct.

Contribution

We encourage contribution to the Open Systems Pharmacology community. Before getting started please read the contribution guidelines. If you are contributing code, please be familiar with the coding standard.

License

The model code is distributed under the GPLv2 License.

References

[1] Kanacher, T. et al. A Physiologically-Based Pharmacokinetic (PBPK) Model Network for the Prediction of CYP1A2 and CYP2C19 Drug–Drug–Gene Interactions with Fluvoxamine, Omeprazole, S-mephenytoin, Moclobemide, Tizanidine, Mexiletine, Ethinylestradiol, and Caffeine. Pharmaceutics 2020, 12(12), 1191

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ethinylestradiol-model's Issues

Mention formulation used for BNack 1979 po

Maybe worth mentioning which formulation was used for Back 1979 po (NA in the table)?
(The same applies to all other reports where po formulation is not given)

Originally posted by @Yuri05 in Open-Systems-Pharmacology/OSP-PBPK-Model-Library#64 (comment)

Update model and evaluation plan and create new release

Convert hyperlinks to lower case

One of our automated link checkers is unfortunately case sensitive.
To avoid false alarms all links must be written in lower case.

False alarms because of case sensitive error check

    
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