multitalk / mirtalk

Extracellular vesicle-derived miRNA-mediated cell-cell communication inference for single-cell transcriptomic data

Hi there, I am Shao, Xin 🎓

and I am mainly engaged in the research of single-cell and spatial omics, cell-cell communication, and liver disease omics with machine learning and deep learning methods.

mirtalk's Issues

Questions about the number of microRNAs

To developers

miRTalk is an interesting work, but I have some doubts. What do you think of the fact that it is almost difficult to detect micro RNA in the 10X data. According to 10X genomic, almost no mature micro RNA can be detected in the data (Ref 1-2). As in the Demo data, only 60+ micro RNAs were detected in the end.

Ref 1-2:
https://kb.10xgenomics.com/hc/en-us/articles/360002004271-Is-it-possible-to-capture-microRNAs-in-the-Gene-Expression-assays-
https://kb.10xgenomics.com/hc/en-us/articles/217261666-What-types-of-RNA-can-be-detected-

with regards,
Xinyan Yang