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View Code? Open in Web Editor NEWPyramidal Neuron: Deep, Thalamic Relay and Reticular, Interneuron (Destexhe et al 1998, 2001)
Home Page: https://modeldb.science/3817
Pyramidal Neuron: Deep, Thalamic Relay and Reticular, Interneuron (Destexhe et al 1998, 2001)
Home Page: https://modeldb.science/3817
NEURON DEMO FOR SIMULATING DIFFERENT CLASSES OF CORTICAL NEURONS Alain Destexhe CNRS, UNIC (Bat-33), Avenue de la Terrasse, 91198 Gif-sur-Yvette, France [email protected] http://cns.iaf.cnrs-gif.fr This package is running with the NEURON simulation program written by Michael Hines and available on internet at: http://www.neuron.yale.edu The package contains mechanisms (.mod files) and programs (.oc files) needed to simulate single-compartment models of cortical neurons. Details of the kinetics of currents are given in: Destexhe A and Sejnowski TJ. Thalamocortical Assemblies. Oxford University Press, 2001 See also the original paper: Destexhe A, Contreras D and Steriade M. Mechanisms underlying the synchronizing action of corticothalamic feedback through inhibition of thalamic relay cells. J. Neurophysiol. 79: 999-1016, 1998. Destexhe A, Contreras D and Steriade M. LTS cells in cerebral cortex and their role in generating spike-and-wave oscillations. Neurocomputing 38: 555-563, 2001. (see electronic copy at http://cns.iaf.cnrs-gif.fr) PROGRAMS ======== demo_PY_RS.oc : regular-spiking pyramidal neuron demo_PY_LTS.oc : bursting pyramidal neuron (LTS cell) demo_IN_FS.oc : fast-spiking interneuron MECHANISMS ========== HH2.mod : fast sodium spikes (Na and K currents) IM.mod : slow voltage-dependent potassium current (IM) IT.mod : T-type calcium current cadecay.mod : intracellular calcium dynamics HOW TO RUN ========== Use autolaunch on modeldb or: unix platform: To compile the demo, NEURON and INTERVIEWS must be installed and working on the machine you are using. Just type "nrnivmodl" to compile the mechanisms given in the mod files. Then, execute the main demo program by typing: nrngui mosinit.hoc mswin platform: Compile the mechanism (mod) files by using mknrndll. Then start the simulation by clicking on mosinit.hoc in windows explorer. back to any platform: Once the menu and graphics interface has appeared, select a simulation from the "Simulations of cortical cells" window. Reposition the windows to find the Run Control window. Then click on "Init and Run" button to start the simulation... For more information about how to get NEURON and how to install it, please refer to the following sites: http://www.neuron.yale.edu http://www.neuro.duke.edu For further information, please contact: Alain Destexhe CNRS, UNIC (Bat-33), Avenue de la Terrasse, 91198 Gif-sur-Yvette, France email: [email protected] http://cns.iaf.cnrs-gif.fr 7/11/2005 Changes added which removes electrode on subsequent simulations. Note: 3/9/2002 Michael Hines made non-substantive changes to allow the 3 demos to run in the same NEURON process. Thus the original button panel was replaced by a radio button panel, and any files which should only be opened once per NEURON launch are now opened via load_file instead of xopen. Lastly, before the gui for each demo is started the previous gui is erased with the restart() procedure which was added to rundemo.hoc 20120109 updated SOLVE method in cadecay.mod to derivimplicit and IM.mod, IT.mod to cnexp as per http://www.neuron.yale.edu/phpbb/viewtopic.php?f=28&t=592
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