modeldbrepository / 267355 Goto Github PK
View Code? Open in Web Editor NEWAIS model of L5 cortical pyramidal neuron (Filipis et al., 2023)
Home Page: https://modeldb.science/267355
AIS model of L5 cortical pyramidal neuron (Filipis et al., 2023)
Home Page: https://modeldb.science/267355
NEURON model files from the paper Luiza Filipis, Laila Ananda Blömer, Jérôme Montnach, Michel De Waard, Marco Canepari Nav1.2 and BK channels interaction shapes the action potential in the axon initial segment Starting from the model of Hallermann et al.2012 the axon was modified to reproduce our experimental results while the rest of the neuron was intact. Use the mosinit file to run the model. To reproduce Figure 6, use the different buttons that appear to run the control experiment, the huwentoxin experiment, the apamin experiment, the iberiotoxin experiment or the VGCCs block accordingly. The experimental data we used to fit the sodium, calcium and Voltage are included. For this model we used NEURON 8.0 on Windows environment. Questions regarding this model should be directed to [email protected] or [email protected] Changelog --------- 2023-05-30: fix for compatibility with the upcoming NEURON 9 release, specifically neuronsimulator/nrn#1992 on GitHub.
The rate procedure has been substantially changed from the source - is this model really representative of an SK channel?
from SK.mod:
PROCEDURE rate(tcai (mM), ncai(mM)) {
LOCAL q10 : not in use, should be removed
q10 = Cq10^((celsius - 22 (degC))/10 (degC) ) : not in use, should be removed
a = a0*(tcaicarco+ncaicahco)/10 : is this dynamics really representative of an SK channel? (why divide by 10? better update a0)
if (a < 0.05) { : why this conditional statement?
a = 0
}
taun = b0 : 0.06, why set this here?
ninf = a : why use a, you could calc ninf diectly above
}
from source (https://pubmed.ncbi.nlm.nih.gov/30048468/):
PROCEDURE rate(cai (mM)) {
LOCAL q10
q10 = Cq10^((celsius - 22 (degC))/10 (degC) )
a = a0cai^4
taun = mt * q10 (0.2*(q10/(a + b0)))
ninf = a/(a + b0)
}
A declarative, efficient, and flexible JavaScript library for building user interfaces.
🖖 Vue.js is a progressive, incrementally-adoptable JavaScript framework for building UI on the web.
TypeScript is a superset of JavaScript that compiles to clean JavaScript output.
An Open Source Machine Learning Framework for Everyone
The Web framework for perfectionists with deadlines.
A PHP framework for web artisans
Bring data to life with SVG, Canvas and HTML. 📊📈🎉
JavaScript (JS) is a lightweight interpreted programming language with first-class functions.
Some thing interesting about web. New door for the world.
A server is a program made to process requests and deliver data to clients.
Machine learning is a way of modeling and interpreting data that allows a piece of software to respond intelligently.
Some thing interesting about visualization, use data art
Some thing interesting about game, make everyone happy.
We are working to build community through open source technology. NB: members must have two-factor auth.
Open source projects and samples from Microsoft.
Google ❤️ Open Source for everyone.
Alibaba Open Source for everyone
Data-Driven Documents codes.
China tencent open source team.