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AIS model of L5 cortical pyramidal neuron (Filipis et al., 2023)

Home Page: https://modeldb.science/267355

AMPL 96.60% C 3.40%
action-potentials-action-potential-initiation-axon neocortex-layer-5-pyramidal-cell neuron-simulator

267355's Introduction

NEURON model files from the paper 
Luiza Filipis, Laila Ananda Blömer, Jérôme Montnach, Michel De Waard, Marco Canepari
Nav1.2 and BK channels interaction shapes the action potential in the axon initial segment
 
Starting from the model of Hallermann et al.2012 the axon was modified to reproduce our 
experimental results while the rest of the neuron was intact.

Use the mosinit file to run the model.

To reproduce Figure 6, use the different buttons that appear to run the control experiment, the huwentoxin experiment, 
the apamin experiment, the iberiotoxin experiment or the VGCCs block accordingly.

The experimental data we used to fit the sodium, calcium and Voltage are included.

For this model we used NEURON 8.0 on Windows environment. 


Questions regarding this model should be directed to
[email protected] 
or
[email protected]

Changelog
---------
2023-05-30: fix for compatibility with the upcoming NEURON 9 release,
            specifically neuronsimulator/nrn#1992 on GitHub.

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267355's Issues

IS SK.mod really representative of an SK channel?

The rate procedure has been substantially changed from the source - is this model really representative of an SK channel?

from SK.mod:
PROCEDURE rate(tcai (mM), ncai(mM)) {
LOCAL q10 : not in use, should be removed
q10 = Cq10^((celsius - 22 (degC))/10 (degC) ) : not in use, should be removed
a = a0*(tcaicarco+ncaicahco)/10 : is this dynamics really representative of an SK channel? (why divide by 10? better update a0)
if (a < 0.05) { : why this conditional statement?
a = 0
}
taun = b0 : 0.06, why set this here?
ninf = a : why use a, you could calc ninf diectly above
}

from source (https://pubmed.ncbi.nlm.nih.gov/30048468/):
PROCEDURE rate(cai (mM)) {
LOCAL q10
q10 = Cq10^((celsius - 22 (degC))/10 (degC) )
a = a0cai^4
taun = mt * q10 (0.2*(q10/(a + b0)))
ninf = a/(a + b0)
}

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