mattfeng / cancer-sensitivity

predicting sensitivity of cancer cells to different drugs

Predicting the sensitivity of cancer cell types to different drugs

Dependencies

• conda install -c conda-forge rdkit

Preprocessing

Compounds metadata

• original source of compound info: https://www.cancerrxgene.org/compounds#t-all

TODO

• integrate latent embedding of cell line genome (mutations)
  • model should be able to learn how immortalization of a cell line influences biology and therefore drug sensitivities; model may need primary cells for comparison, but overall the idea is to use machine learning to correct for the cell line's imperfect modeling of a primary cell