maromasamsa / fnirs-experiment

ARMT invervention experiment flow (Healthy subject)

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Objective:

Compare the upper limb rehabilitation performance of traditional mirror therapy and augmented reality mirror therapy (ARMT)

Subject

:::info Recruit from WTMH Lab and other BME lab member :::

Find at least 10, at most 30 subjects to join the intervention experiment, All subjects should be right-handed and should be unfamiliar with the mirror therapy. subjects did not have musculoskeletal or neurological defect and did not have visual impairment.

Rehearsal

:::info Site: Electrical engineering classroom :::

• Check the place experiment take, set up fNIRS, run through the software and collect the raw data.
• If fNIRS is not been used in the period by other labs, left it to stand by in the electrical engineering classroom.

Selected date

• 2022/9/13 ::: 13:10 - 17:00
• 2022/9/14 ::: 13:10 - 17:00
• 2022/9/16 ::: 13:10 - 17:00

Discuss with professor Su's Lab which day is prefer.

Period of formal intervention

:::warning This schedul have not discuss with professor Su yet, may be changed in the future :::

September 2022

• 9/20 (W2)
• 9/21 (W3)
• 9/27 (W2)
• 9/28 (W3)
• 9/30 (W5)

October 2022

• 10/4 (W2)
• 10/5 (W3)
• 10/7 (W5)
• 10/11 (W2)
• 10/12 (W3)
• 10/14 (W5)
• 10/18 (W2)
• 10/19 (W3)
• 10/21 (W5)
• 10/25 (W2)
• 10/26 (W3)
• 10/28 (W5)

:::info [Time: 13:10 - 17:10] [At: Electrical engineering classroom] [Two subjects per day]

• At least choose 10 day, 10 subject, each healthy subject will have twice intervention, one is traditional mirror therapy, the other one is ARMT.
• The interval between the two intervention times needs to be more than one week, as the cleaning period. :::

---

Intervention

graph TD;

A[Select subjects]
B[1:1 Randomization]
C1[MT <br> Once, 10 min fNIRS + 20 min therapy]
C2[ARMT <br> Once, 10 min fNIRS + 20 min therapy]
E1[ARMT <br> Once, 10 min fNIRS + 20 min therapy]
E2[MT <br> Once, 10 min fNIRS + 20 min therapy]

G1[Group1]
G2[Group2]

A --> B
B --> G1 --> C1
B --> G2 --> C2
C1 --One week washout--> E1
C2 --One week washout--> E2

INFO[Evaluated by fNIRS, pre-test and post-test]

E1 --- INFO
E2 --- INFO

Select subjects

:::info Recruit from WTMH Lab and other BME lab member :::

Find at least 10, at most 30 subjects to join the intervention experiment, All subjects should be right-handed and should be unfamiliar with the mirror therapy. subjects did not have musculoskeletal or neurological defect and did not have visual impairment.

Evaluation

Pre-test and post-test

:::success This part will be handled by Dr. Xu :::

1. Pinch-holding-up-activity test, PHUA test
2. Semmes-Weinstein monofilament, SWM
3. Two-point Discrimination Test, 2PD)
4. Purdue Pegboard Test
5. Minnesota Manual Dexterity Test, MMDT

fNIRS

According to the literature research and Dr. Xu's IRB proposal, the following cortex regions will be selected:

1. brain prefrontal cortex
2. premotor cortex
3. primary motor cortex
4. supplementary motor cortex
5. sensorimotor cortex
6. secondary sensory cortex

https://github.com/maromaSamsa/fNIRS-experiment/blob/main/fOLD/fOLD.png

The fNIRS chennel will be set with reference to this chart

https://github.com/maromaSamsa/fNIRS-experiment/blob/main/fOLD/fOLD.png

Subject schematic

Intervention schedule for single subject

Each healthy subject will have twice intervention, one is the traditional mirror therapy, the other one is ARMT.

Experimental procedure

• Pre-test will take place in NCKU Hospital Rehabilitation Department
• Next, for the purpose of collecting fNIRS signal, there will have ten minutes intervention will take place in NCKU BME Electrical Engineering Classroom.
• In the ten minutes recording fNIRS time, the subject will only be asked to perform finger pinching, by their non-dominant hand.
• Depending on the group to which they were assigned, subjects were asked to observe with their eyes a mirrored hand (their dominant hand) generated through a mirror or VR headset.
• After finish recording, subject will back to NCKU Hospital Rehabilitation Department to do the post test.

digraph {
    node[shape=record]
    splines = false
    rankdir = "LR"
    
    subgraph cluster01 {
        label="Experimental procedure (90 minutes)"
        pre [label = "Pre-test | <p>NCKU Hospital | <t> 20 minutes"]
        setup [label = "Setup | <p>BME EE classroom | <t> 10 minutes"]
        trans1 [label = "Transfer | <t> 5 minutes"]
        inter1 [label = "Intervention (fNIRS) | <p>BME EE classroom | <t> 10 minutes", fillcolor = "Turquoise", style = filled]
        trans2 [label = "Transfer | <t> 5 minutes"]
        inter2 [label = "Intervention | <p>NCKU Hospital | <t> 20 minutes"]
        post [label = "Post-test | <p>NCKU Hospital | <t> 20 minutes"]
        
        pre->trans1->setup->inter1
        inter1->trans2->inter2->post
    }
}

digraph {
    node[shape=record]
    splines = false
    rankdir = "LR"
    
    subgraph cluster01 {
        label="fNIRS Intervention (10 minutes)"
        rest1 [label = "Rest | <s>eyes close | <t> 30 seconds", fillcolor = "gainsboro", style = filled]
        pinch1 [label = "Pinching | <s>eyes open | <t> 30 seconds", fillcolor = "coral", style = filled]
        rest2 [label = "Rest | <s>eyes close | <t> 30 seconds", fillcolor = "gainsboro", style = filled]
        pinch2 [label = "Pinching | <s>eyes open | <t> 30 seconds", fillcolor = "coral", style = filled]
        rest3 [label = "Rest | <s>eyes close | <t> 30 seconds", fillcolor = "gainsboro", style = filled]
        pinch3 [label = "Pinching | <s>eyes open | <t> 30 seconds", fillcolor = "coral", style = filled]
        DOT[shape = plaintext, label = "..."]
        
        rest1->pinch1->rest2->DOT->pinch2->rest3->pinch3
    }
}

Each trail box switch between resting and pinching, triggered by an auditory cue. In the resting state, subjects will be asked to let their minds go empty with closing their eyes During the pinching state, the subjects were asked to observe their mirrored hand.