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View Code? Open in Web Editor NEWFine-mapping method only using summary statistics
Fine-mapping method only using summary statistics
---------------------- Copyright ---------------------- Copyright (c) 2016, Hailiang Huang, Padhraig Gormley and Mark J Daly, Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston MA All rights reserved. Redistribution and use in source and binary forms, with or without modification, are permitted provided that the following conditions are met: 1. Redistributions of source code must retain the above copyright notice, this list of conditions and the following disclaimer. 2. Redistributions in binary form must reproduce the above copyright notice, this list of conditions and the following disclaimer in the documentation and/or other materials provided with the distribution. THIS SOFTWARE IS PROVIDED BY THE COPYRIGHT HOLDERS AND CONTRIBUTORS "AS IS" AND ANY EXPRESS OR IMPLIED WARRANTIES, INCLUDING, BUT NOT LIMITED TO, THE IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE ARE DISCLAIMED. IN NO EVENT SHALL THE COPYRIGHT OWNER OR CONTRIBUTORS BE LIABLE FOR ANY DIRECT, INDIRECT, INCIDENTAL, SPECIAL, EXEMPLARY, OR CONSEQUENTIAL DAMAGES (INCLUDING, BUT NOT LIMITED TO, PROCUREMENT OF SUBSTITUTE GOODS OR SERVICES; LOSS OF USE, DATA, OR PROFITS; OR BUSINESS INTERRUPTION) HOWEVER CAUSED AND ON ANY THEORY OF LIABILITY, WHETHER IN CONTRACT, STRICT LIABILITY, OR TORT (INCLUDING NEGLIGENCE OR OTHERWISE) ARISING IN ANY WAY OUT OF THE USE OF THIS SOFTWARE, EVEN IF ADVISED OF THE POSSIBILITY OF SUCH DAMAGE. The views and conclusions contained in the software and documentation are those of the authors and should not be interpreted as representing official policies, either expressed or implied, of the FreeBSD Project. ---------------------- Synopsis ---------------------- A simplified fine-mapping method that only requires summary statistics. It only maps the primary signal and uses flat prior with steepest descent approximation. ---------------------- Usage ---------------------- open your R console use 'source("getCredible.r")' to run this program with the supplied toy data
Dear Dr.Huang,
What is the principle of the threshold setting (“R2_threshold <- 0.4”)? Can I lower the threshold?
I look forward to receiving your response.
Thank you!
Yours sincerely,
Wenqiang Zhang
Department of Epidemiology and Biostatistics
West China School of Public Health and West China Fourth Hospital, Sichuan University
No. 16, Section 3, South Renmin Road, Wuhou District, Chengdu 610041, China
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