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GEAR [GEnetic Analysis Repository], contact [email protected];

Home Page: https://github.com/gc5k/GEAR/wiki

Java 100.00%
statistical-genetics java summary-statistics eigengwas haseman-elston

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gear's Issues

--mpheno problem

Diao Shuqi reported a bug in
gear.subcommands.CommandArguments.setPhenotypeIndex(String[] pheIndex)

the problem is that I incorrectly wrote "this.mPheno[i]--;"
I've removed it now.

see this commit.

two *.egwas files?

I do eigengwas analysis for my wheat population. The population included two subgroup.

The commond is jar gear.jar eigengwas --bfile MCC_genotype_filter2 --inbred --ev 2 --out wheat125

The result included two files wheat125.1.egwas and wheat125.1.egwas.

Could you tell me which file is right?

RAF_SE columns in the GWAS summary statistic

Hi there,
When I try to compute Fst using GEAR, I found there is no RAF_SE columns in my GWAS summary statistics and in 1KG reference panel frq.file.
How can I get RAF_SE columns? Should I sample the GWAS SNPs matched to the 1KG reference samples?
I'm not really sure what is going on. Thank you in advance for your help!

Wrong Description in DNA Fingerprint wiki

--m Specify the number of markers for generating similarity scores between individuals. It defaults to use all markers.
but It defaults to use 100 markers……

--low-cutoff/--l

Specify the lower bounder for similarity cutoff. Only the similarity score lower than the given cutoff will be printed out.

--high-cutoff/--h

Specify the upper bounder for similarity cutoff. Only the similarity score lower higher than the given cutoff will be printed out.

Does not accept column OR

Dear developers,

I am trying to run "java -jar gear.jar lam --meta-batch sum_stat_files.txt --qt-size sum_stat_size.txt --out test" on two summary stats files to see if there are overlapping samples.

The header of the first file is:
CHR SNP BP A1 A2 OR SE P
And the header of the second is:
CHR SNP BP A1 A2 BETA SE P

When I run the command I get:

[INFO]
[INFO] The keyword for 'SNP' is set to snp
[INFO] The keyword for 'BETA' is set to beta
[INFO] The keyword for 'SE' is set to se
[INFO] The keyword for 'A1' (reference allele) is set to a1
[INFO] The keyword for 'A2' (the other allele) is set to a2
[INFO] The keyword for 'CHR' is set to chr

[INFO] 2 cohorts are remained for analysis.

[INFO] Cannot find the beta/or column in SCZvsCONT_new.sumstats
[INFO] GEAR quit.

Can you please help me with that?

BEDReader

Two reset methods are needed.

  1. reset() to the very beginning of the genotype stream
  2. rollback(k) k individuals.

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