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SKP2 knockout in Rb1/p53 deficient mouse models of osteosarcoma induces immune infiltration and drives a transcriptional program with a favorable prognosis

Ferrena et al, Molecular Cancer Therapeutics 2023

Alexander Ferrena ; Jichuan Wang ; Ranxin Zhang ; Burcu Karadal-Ferrena ; Waleed Al-Hardan ; Swapnil Singh ; Hasibagan Borjihan ; Edward L. Schwartz ; Hongling Zhao ; Maja H. Oktay ; Rui Yang ; David S. Geller ; Bang H. Hoang ; Deyou Zheng

https://doi.org/10.1158/1535-7163.MCT-23-0173

  1. Analysis of bulk RNA-seq data for TKO vs DKO transgenic mice.
  2. Analysis of human patients including TKO signatures and immune deconvolution in patients along with survival analysis; macrophage SKP2 correlations, in two OS cohorts and pan-cancer TCGA.

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