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cbravo93 avatar cbravo93 commented on June 24, 2024

Hi!

Which function are you using exactly? For parameter optimization we use Collapsed Gibbs Sampling, I think this is different in the default sklearn function (they use VEM if I remember correctly?). If you read our paper (https://www.nature.com/articles/s41592-019-0367-1#Sec20), in FigS1 we compared the effect of several parameter estimation methods and found that only collapsed gibbs sampling works well with this type of data.

Cheers!

C

from cistopic.

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