Coder Social home page Coder Social logo

Feature: Align and Extend about teloclip HOT 5 OPEN

adamtaranto avatar adamtaranto commented on September 25, 2024
Feature: Align and Extend

from teloclip.

Comments (5)

Adamtaranto avatar Adamtaranto commented on September 25, 2024

Proposed modules names:

teloclip filter
teloclip extract
teloclip extend

from teloclip.

Adamtaranto avatar Adamtaranto commented on September 25, 2024

#10 requests automation of the contig extension process. I think it is generally unwise to blindly accept overhang alignments are "real" without inspecting them first.

Need to balance convenience vs enabling errors.

Could provide tutorial on manual curation: Select the best overhang-read (i.e. confident anchor region, unique alignment, many reads agree) and then extend contig with teloclip extend.

Alternatively, could provide an extend-now-ask-questions-later option whereby we extend contigs using the longest available overhang and then suggest validation checks i.e. align all overhang-reads back to the extended contig and look for agreement between reads.

from teloclip.

Adamtaranto avatar Adamtaranto commented on September 25, 2024

Add output option for extract to yield MAF or MSA of overhang-reads that can be viewed in terminal or externally.

from teloclip.

Adamtaranto avatar Adamtaranto commented on September 25, 2024

Note: Log total bases extended and bases per contig end. Useful for reporting results.

from teloclip.

Adamtaranto avatar Adamtaranto commented on September 25, 2024

Option: Output BED file coords for extended sequence segments for review.

from teloclip.

Related Issues (20)

Recommend Projects

  • React photo React

    A declarative, efficient, and flexible JavaScript library for building user interfaces.

  • Vue.js photo Vue.js

    🖖 Vue.js is a progressive, incrementally-adoptable JavaScript framework for building UI on the web.

  • Typescript photo Typescript

    TypeScript is a superset of JavaScript that compiles to clean JavaScript output.

  • TensorFlow photo TensorFlow

    An Open Source Machine Learning Framework for Everyone

  • Django photo Django

    The Web framework for perfectionists with deadlines.

  • D3 photo D3

    Bring data to life with SVG, Canvas and HTML. 📊📈🎉

Recommend Topics

  • javascript

    JavaScript (JS) is a lightweight interpreted programming language with first-class functions.

  • web

    Some thing interesting about web. New door for the world.

  • server

    A server is a program made to process requests and deliver data to clients.

  • Machine learning

    Machine learning is a way of modeling and interpreting data that allows a piece of software to respond intelligently.

  • Game

    Some thing interesting about game, make everyone happy.

Recommend Org

  • Facebook photo Facebook

    We are working to build community through open source technology. NB: members must have two-factor auth.

  • Microsoft photo Microsoft

    Open source projects and samples from Microsoft.

  • Google photo Google

    Google ❤️ Open Source for everyone.

  • D3 photo D3

    Data-Driven Documents codes.