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Implement MCP methods about pertpy HOT 1 OPEN

theislab avatar theislab commented on June 14, 2024
Implement MCP methods

from pertpy.

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Zethson avatar Zethson commented on June 14, 2024

TODO list

  • Implement DIALOGUE 2
  • Add DIALOGUE 3
  • Separate load and calculate_multifactor_PMD calculation -> have two separate function calls for these; load should store stuff in the AnnData object already
  • Rename the MCPs to something better and not just 0, 1, ...
  • Rewrite the MCP concatenation to ensure that we're not returning an AnnData object but modifying inplace
  • Write tests for the functions
  • Solve TODOs
  • Add plotting functions from DIALOGUE R
  • Think about factoring all DIALOGUE 1, DIALOGUE 2 and DIALOGUE 3 steps into their own Python files aka create a private _dialogue module
  • remove new_mcp_scores from multilevel_modeling and expose calculate_cca_sig
  • ensure calculate_cca_sig and multilevel_modeling can be called separately
  • Store the most used parameters in the DIALOGUE object -> e.g. sample etc
  • hierarchical modeling only returns results for 1 cell type -> why?!? Is the result being overwritten?
  • results from hierarchical modeling should not return sig_genes per cell type pair but rather per cell type
  • make sure user is aware that n_UMI needs to be logged if .X is logged
  • multilevel_modeling does not allow for confounder to be None -> code breaks (ignore type hints)

from pertpy.

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