[MAME (Or probably more)] - Can't load files that are more than 2 GBs about bizhawk

[CasualPokePlayer]

This is due to the "ROMs" being sent in byte arrays, which have a 2GiB limit. This is kind of a limit which isn't really easy to bypass, besides having a ton of extra handling for CHDs (which would probably be wanted anyways), but that involves changing a bit of internal MAME code here and not trivial.

In general this is a non-issue anyways, CDs (which would be the typical "large file" case here) don't get sent directly, rather they have wrappers to handle them and the core doesn't interact with some memory bound byte buffer with them (instead just grabbing them from disk if needed via these wrappers), and the only other core which has potentially large files is Encore (3DS roms can be greater than 2GiBs), which just gets sent the file path without ever loading into memory (sort of a hack but eh).