Comments (7)
During our offline discussion on Monday we decided that yeast-GEM
should remain S288c-specific, to stick with the long-running consensus that the S. cerevisiae GEMs are based on this strain. So non-S288c genes should be removed from this model.
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@BenjaSanchez
These two genes could be found from SGD
https://www.yeastgenome.org/locus/S000125021
https://www.yeastgenome.org/locus/S000029723
They are not belong to S288c, but also for the yeast. These two genes are from iSce926.
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@hongzhonglu should then be removed? We should only keep genes belonging to the strain of the model I think.
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@BenjaSanchez As we discussed in last meeting, the present yeast-GEM will be developed as pan-model of Saccharomyces cerevisiae. The strain specific model will be obtained based on yeast-GEM. In this case, it is OK to include these two genes.
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@BenjaSanchez @hongzhonglu The general yeast-GEM
consensus model should describe one species also due to strain-specific gapfilling and curation, and s288c has been the standard for S .cerevisiae models. We schould schedule a meeting to brainstorm and formalize how to deal with non-S288c genes and reactions, I already have some ideas, and then decide on how to deal with these two genes and similar instances.
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@edkerk @BenjaSanchez Great! We are also thinking about it. So when are you free?
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Thanks a lot, @edkerk, @BenjaSanchez and @hongzhonglu . Now, my life is easier.
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Related Issues (20)
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