shwenwen / tisch2

Tumor Immune Single-cell Hub update

TISCH2

The updated Tumor Immune Single-cell Hub (TISCH2) is a scRNA-seq database, which focuses on tumor microenvironment (TME). TISCH provides detailed cell-type annotation for all curated datasets, enabling the exploration of TME across different cancer types.

Release 1 - July 11th, 2020

Release 2 - September 30th, 2022

Data statistics

• 50 cancer types.
• 190 datasets: 40 datasets with ICB treatment (35 for human and 5 for mouse), 147 non-ICB datasets and 3 PBMC datasets.
• 6,297,320 cells: 1,227,590 malignant cells and 5,069,730 non-malignant cells.

New Functions & Features

Dataset Module

• TF enrichment: Find the potential transcription factors of each cluster in every dataset.
• CCI analysis: 1. A heatmap shows an overview of cell-cell interaction number between different cell clusters; 2. The detail interaction information for a selected cluster (circus plot); 3. The significant ligand-receptor pairs in of source and target clusters (bubble plot).

Gene Module

• Survival: Find the potential transcription factors of each cluster in every dataset.
• Gene-gene correlation: 1. A heatmap shows an overview of cell-cell interaction number between different cell clusters; 2. The detail interaction information for a selected cluster (circus plot); 3. The significant ligand-receptor pairs in of source and target clusters (bubble plot).