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Hi there 👋

I'm Michael, a computational biologist. This means that I'm using computers and code to analyze biological data, often in collaboration with experimental scientists. I'm working on how cancer cells overcome their growth limitations and how we can use that to help patients. Here you can find some of the work I did, and more general purpose tools I wrote for anyone to use. Please reach out if you want to collaborate!

This is what I do for research 👨‍🔬 (full list 🔗)
            article                     code         
Developed a reliable method for estimating cell signaling pathways from gene expression Nat Comm
Cell
github :octocat:
bioc 📦
Showed how gene coexpression networks often reflect cell mixtures instead of regulation BBA-GRM github :octocat:
Found a way how cancer cells can tolerate abnormal DNA content (aneuploidy, chromosomal instability) and a potential treatment, in collaboration with experimental scientists bioRxiv
Nature
transposon :octocat:
cgas_ko :octocat:
Working on estimating DNA copy number of single-cell RNA sequencing coming soon
Here are some of my open source contributions 🔠 (full list 🔗)
            status                     code         
clustermq R package for efficient high performance computing
Bioinformatics downloads
CRAN version
Build Status
github :octocat:
cran 📦
testing ⚙️
narray R package for simplifying array operations
downloads
CRAN version
Build Status
github :octocat:
cran 📦
ebits R bioinformatics toolkit incubator and data API Build Status ebits :octocat:
data :octocat:
Software build scripts for the ArchLinux User Repository 🔗 and as Gentoo overlay 🔗 pkgcheck pkgbuilds :octocat:
overlay :octocat:

Michael Schubert's Projects

arrayexpress icon arrayexpress

This is a read-only mirror of the Bioconductor SVN repository. Package Homepage: http://bioconductor.org/packages/devel/bioc/html/ArrayExpress.html Bug Reports: https://support.bioconductor.org/p/new/post/?tag_val=ArrayExpress.

biomodels_curation icon biomodels_curation

Scripts used for curation of Blood Coagulation models for the BioModels database

boundie icon boundie

R package for differential expression on count data with parameter bounds

clustermq icon clustermq

R package to send function calls as jobs on LSF, SGE, Slurm, PBS/Torque, or each via SSH

cppzmq icon cppzmq

Header-only C++ binding for libzmq

data icon data

A data API for molecular biology

ebits icon ebits

R bioinformatics toolkit incubator

footprints icon footprints

Analysis code for "Perturbation-response genes reveal signaling footprints in cancer gene expression"

genie3 icon genie3

GENIE3 (GEne Network Inference with Ensemble of trees) R-package

gentoo icon gentoo

The official mirror the Gentoo ebuild repository (now in true git!)

gentoo_prefix_ci icon gentoo_prefix_ci

A Gentoo Prefix continuous integration repo. Find precompiled Gentoo Prefix in the releases section

grn-aneup-purity icon grn-aneup-purity

Analysis code for "Gene networks in cancer are biased by aneuploidies and sample impurities"

honeybadger icon honeybadger

HMM-integrated Bayesian approach for detecting CNV and LOH events from single-cell RNA-seq data

mad2-transposon icon mad2-transposon

Analysis code for "Cancer tolerance to chromosomal instability is driven by Stat1 inactivation in vivo"

mcp icon mcp

Regression with Multiple Change Points

narray icon narray

R package for subset- and name-aware array utility functions

overlay icon overlay

Gentoo overlay for (mainly scientific) software that's not quite ready for the main tree

pkgbuilds icon pkgbuilds

Build scripts for the Archlinux User Repository

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