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Can BONE handle admixture? about bone HOT 1 OPEN

markkukuismin avatar markkukuismin commented on September 21, 2024
Can BONE handle admixture?

from bone.

Comments (1)

markkukuismin avatar markkukuismin commented on September 21, 2024

Hello Kris,

the admixture in the baseline is not taken into account in the model part of the BONE procedure and very strong admixture in the baseline populations has an effect on the assignment accuracy. If you want to use BONE, I recommend that you use the WTA method which can somewhat mitigate the assignment error caused by the admixture in the baseline populations.

Best,
Markku

from bone.

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