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jdavisturak's Projects

bam2ssj icon bam2ssj

Utility for FAST counting splice site junctions and related information from BAM files.

ctcsmodel icon ctcsmodel

When messenger RNA splicing occurs co-transcriptionally, the potential for kinetic control based on transcription dynamics is widely recognized. Indeed, perturbation studies have reported that when transcription kinetics are perturbed genetically or pharmacologically splice patterns may change. However, whether kinetic control is contributing to the control of splicing within the normal range of physiological conditions remains unknown. We examined if the kinetic determinants for co-transcriptional splicing (CTS) might be reflected in the structure and expression patterns of the genome and epigenome. To identify and then quantitatively relate multiple, simultaneous CTS determinants, we constructed a scalable mathematical model of the kinetic interplay of RNA synthesis and CTS and parameterized it with diverse next generation sequencing (NGS) data. We thus found a variety of CTS determinants encoded in vertebrate genomes and epigenomes, and that these combine variously for different groups of genes such as housekeeping versus regulated genes. Together, our findings indicate that the kinetic basis of splicing is functionally and physiologically relevant, and may meaningfully inform the analysis of genomic and epigenomic data to provide insights that are missed when relying on statistical approaches alone.

diffbind icon diffbind

This is a branch from the mirror of the Bioconductor SVN repository. Package Homepage: http://bioconductor.org/packages/devel/bioc/html/DiffBind.html Bug Reports: https://support.bioconductor.org/p/new/post/?tag_val=DiffBind.

focus icon focus

A model to identify organisms present in metagenomes in seconds

libstatgen icon libstatgen

Useful set of classes for creating statistical genetic programs.

mariadb icon mariadb

Docker Official Image packaging for MariaDB

mosaics icon mosaics

MOdel-based one and two Sample Analysis and Inference for ChIP-Seq

pangolin icon pangolin

Software package for assigning SARS-CoV-2 genome sequences to global lineages.

pygenometracks icon pygenometracks

python module to plot beautiful and highly customizable genome browser tracks

rasl_align icon rasl_align

Pipeline scripts to align reads generated by RASL-seq

sctyper icon sctyper

scTyper: a comprehensive pipeline for the cell typing analysis of single-cell RNA-seq data

seq_pipeline icon seq_pipeline

Pipeline for analysis of SEQ data from the UCLA sequencing core, using STAR as main aligner and htseq-count

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