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Open source code for AlphaFold.
sensitive alignment of genomes with high sequence diversity, extensive structural polymorphism and whole-genome duplication variation
整合型的对于生物学注释的信息/GO和KEGG全谱注释和富集
Integrated analysis of genomes, transcriptomes, proteomes and drug responses of cancer cell lines (CCLs) is an emerging approach to uncover molecular mechanisms of drug action. We extend this paradigm to measuring proteome activity landscapes by acquiring and integrating quantitative data for 10,000 proteins and 55,000 phosphorylation sites (p-sites) from 125 CCLs. These data are used to contextualize proteins and p-sites and predict drug sensitivity. For example, we find that Progesterone Receptor (PGR) phosphorylation is associated with sensitivity to drugs modulating estrogen signaling such as Raloxifene. We also demonstrate that Adenylate kinase isoenzyme 1 (AK1) inactivates antimetabolites like Cytarabine. Consequently, high AK1 levels correlate with poor survival of Cytarabine-treated acute myeloid leukemia patients, qualifying AK1 as a patient stratification marker and possibly as a drug target. We provide an interactive web application termed ATLANTiC (http://atlantic.proteomics.wzw.tum.de), which enables the community to explore the thousands of novel functional associations generated by this work.
Automatic MARTINI parametrization of small organic molecules
Toolkit for concretely describing non-canonical DNA, RNA, and proteins
The final version 2 release of our software to detect core genes in eukaryotic genomes
a versatile and flexible pipeline for analysing different variants of ChIA-PET data
the package manager for JavaScript
collocation analysis of genomics regions
This repository contains implementations and illustrative code to accompany DeepMind publications
DeepWAS: Directly integrating regulatory information into GWAS using machine learning
DevilYuan量化交易平台 可视化股票量化系统,支持选股,历史数据自动下载,策略回测及参数优化,实盘交易和常用的统计功能
Extensive de-novo TE Annotator
Finder of Somatic Fusion Genes in RNA-seq data
Extended tools for correlation analysis and visualization.
GOMAP-Singularity is the containerized version of GOMAP
HCASMCeQTLviewer is a combined bash/R/awk script to view eQTL box/dot plots for a specific gene/SNP cis and trans eQTL association in human coronary artery smooth muscle cells, one of the crucial cell types that are involved in atherosclerotic process of the blood vessel.
“When everything is connected to everything else, for better or worse, everything matters.” Bruce Mau
Hifiasm: a haplotype-resolved assembler for accurate Hifi reads
hot_scan is a free software to detect genomic regions unusually rich (hotspot) in a given pattern via scan statistics
Python library to facilitate genome assembly, annotation, and comparative genomics
Software implementing the Latent Causal Variable Model
LD Score Regression (LDSC)
A versatile pairwise aligner for genomic and spliced nucleotide sequences
Some useful scripts or awk program for dealing with gromacs data
A declarative, efficient, and flexible JavaScript library for building user interfaces.
🖖 Vue.js is a progressive, incrementally-adoptable JavaScript framework for building UI on the web.
TypeScript is a superset of JavaScript that compiles to clean JavaScript output.
An Open Source Machine Learning Framework for Everyone
The Web framework for perfectionists with deadlines.
A PHP framework for web artisans
Bring data to life with SVG, Canvas and HTML. 📊📈🎉
JavaScript (JS) is a lightweight interpreted programming language with first-class functions.
Some thing interesting about web. New door for the world.
A server is a program made to process requests and deliver data to clients.
Machine learning is a way of modeling and interpreting data that allows a piece of software to respond intelligently.
Some thing interesting about visualization, use data art
Some thing interesting about game, make everyone happy.
We are working to build community through open source technology. NB: members must have two-factor auth.
Open source projects and samples from Microsoft.
Google ❤️ Open Source for everyone.
Alibaba Open Source for everyone
Data-Driven Documents codes.
China tencent open source team.